Patients with foot ulceration, and especially those with diabetes, are at an increased risk of amputation. All patients with diabetic foot ulcers should undergo objective testing for critical limb ischemia. This paper looks at the results of a delay in revascularization. Patients who underwent revascularization within 2 weeks of initial assessment had better limb salvage rates than those that did not. This article supports the widely accepted perception that when it comes it critical limb ischemia (CLI), Time Matters.
https://www.sirweb.org/advocacy-and-outreach/media/news-release-archive/news-release-uterine_fibroids_study/
This paper is a meta-analysis looking at progression of peripheral arterial disease (PAD).
Pedal loop revascularization procedures are the last resort for patients with no other options for saving their limb.